Catalog "HUMAN GENES ASSOCIATED WITH SPERM ABNORMALITIES CAUSED BY IMPAIRED SPERMATOGENESIS (PATHOZOOSPERMIA)"
Currently, the database contains date of 126 genes with polymorphic loci associated with various pathology manifestation. Common scheme of database HGAPat is shown on the figure 1.
Figure 1. Scheme of the database "HUMAN GENES ASSOCIATED WITH PATHOZOOSPERMIA"
The table Genes contains identifies, symbols, full names and chromosomal localization of genes.
| Field | Description |
|---|---|
| IDGene | |
| Symbol | The symbol of the gene from the database EntrezGene |
| FullName | The full name of the gene from the database EntrezGene |
| MapLocation | Map location (according to ftp://ftp.ncbi.nlm.nih.gov/refseq/H_sapiens/) |
| ExpressionPattern | Specificity of expression = Expression pattern (Testis-specific, testis-enriched, other) |
| GOAnnotation | Response to unfavorable conditions |
The PubGenes contains gene name in article from the article
| Field | Description |
|---|---|
| GeneID | Gene identifier |
| PubMedID | PubMed identifier of the research article |
| OtherGenesName | Other gene name from the article |
The “Disease” table contains the variants of pathology manifestation.
| Field | Description |
|---|---|
| IDDisease | Disease identifier |
| InfertilityPhenotype | Infertility phenotype |
| Manifestation | Manifestation of pathology |
The “GeneticVariant” table is the main table that containes data on associations between allelic variants of genes and specific forms of pathozoospermia
| Field | Description |
|---|---|
| IDRow | Identifier of row |
| GeneID | Gene identifier |
| PubMedID | PubMed identifier of the research article |
| DiseaseID | Pathozoospermia identifier |
| Population | |
| VariantID | Variant ID from dbSNP given in the article |
| Designation | The designation of the variant, as it was used in the article |
| RiskAllele | Name of Allele |
| Location | The location of the variant in gene region (exon, intron, etc.) |
| OddsRatio | Odds ratio |
| LowerOddsRatio | Lower limit of confidence interval of the Odds Ratio |
| UpperOddsRatio | Upper limit of confidence interval of the Odds Ratio |
| DesignationHGVS | Variant designation according to HGVS |
| PhenotypeDetails | Infertility phenotype details (if available in the article) |